S-45A

S-45A was an American satellite, which was lost in a launch failure in 1961. The satellite was intended to operate in a highly elliptical orbit, from which it was to have provided data on the shape of the ionosphere, and on the Earth's magnetic field. It was part of the Explorer programme, and would have been designated Explorer 12 had it reached orbit. It was the second of two identical satellites to be launched; the first, S-45, had also been lost in a launch failure, earlier in the year.

S-45A was launched aboard a Juno II rocket, serial number AM-19G. It was the final flight of the Juno II. The launch took place from Launch Complex 26B at the Cape Canaveral Air Force Station at 19:48:05 UTC on 24 May 1961. The system which was intended to ignite the second stage malfunctioned, and as a result that stage failed to ignite. The rocket failed to achieve orbit.

References

S100A13

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

S100A13 has been shown to interact with SYT1 and FGF1.

Pathology

Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.

S100A11

S100 calcium-binding protein A11 (S100A11) is a protein that in humans is encoded by the S100A11 gene.

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.

Interactions

S100A11 has been shown to interact with Nucleolin and S100B.

References

Further reading

S.O.S. (Too Bad)

"S.O.S. (Too Bad)" is a song by American hard rock band Aerosmith. It was released in 1974 as their third single from their second album Get Your Wings.

Background

Written by Steven Tyler, it is a hard rocking song focusing on sex and sleaze, with a chorus of "I'm a bad, lonely school boy, and I'm a rat, and it's too bad, can't get me none of that." The song starts off with a fast drum beat and basic guitar riff, then slows down, and builds up once again, with Steven Tyler's rapid-fire, fierce lyrics accompanying. The song's lyrical content and musical styles are in the vein of "blooze", a grittier hard rock version of blues music, often with lyrics focused on sex, drugs, and urban life.

The song has remained a fan favorite and has been a staple in the setlists on Aerosmith's most recent tours, the Rockin' the Joint Tour and the Route of All Evil Tour.

S.O.S. stands for "Same Old Shit".

Track listing

References

External links

The Chronicles of Life and Death

The Chronicles of Life and Death is the third full-length studio album by Good Charlotte, released on October 5, 2004, through Daylight Records. The album was released with two different versions: a "Life" and a "Death" version which came with different cover art (designed by guitarist Billy Martin) and a special bonus track. There is also a Japanese version that has a different cover art as well as the special bonus tracks from both the "Life" and "Death" versions, including the hidden track "Wounded" at the end of the album. The Chronicles of Life and Death is the first and only album to feature Chris Wilson on drums.

Composition

The album has been widely considered a departure from their previous two albums, mixing new elements such as lyrical topics into Good Charlotte's youthful sound. Some sources have referred to the album as "emo". The album has different music styles. The opener track "Once Upon A Time: The Battle of Life and Death" is an instrumental opener with strings, a Japanese choir and an organ. "The Truth" is a piano ballad, and "I Just Wanna Live" has a hip hop beat with synthesized strings. Lyrically, the album also focuses on darker and more serious subject matter. "The World Is Black" is about apathy, "S.O.S" is about suicide, and "In This World (Murder) is about corporate greed.

S.O.S. (Pink Lady song)

"S.O.S." is a song Yū Aku and Shunichi Tokura wrote for Japanese idol duo Pink Lady. It was released as the group's second single in November 1976, and became their first number-one hit on the Japanese Oricon singles chart in the following year.

"S.O.S." features Morse code which stands for the song title at the opening of the song. Because its sound effect might be mistaken for genuine Morse code, intro of the track has been omitted occasionally when the song has played on the radio. The song has been one of favorites for both the duo and the fans, and it is also one of the essential songs performed in their concerts.

Reception

Led by commercial success of its predecessor "Pepper Keibu" which reached the number-4 on the Japanese Oricon chart, "S.O.S" climbed the top of the country's hit parade three months after its release. A single remained on the chart for 38 weeks, selling approximately 650,000 copies. According to the record label Victor, "S.O.S." has sold in excess of 1.2 million units to date.